In inflammatory CRS, the cause of olfactory dysfunction is often multifactorial; nasal polyps are a physical barrier to odorant molecules reaching the olfactory epithelium, whereas oedematous mucosa also contributes to this ‘conductive’ problem. Motile cilia on the nasal epithelium may be impaired as a result of the disease process, as can the non-motile (primary) olfactory cilia on the specialised olfactory epithelium that are essential for initiation of the olfactory signalling cascade.
https://thorax.bmj.com/content/73/10/897
The more you know…
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