Beyond the Beat: Understanding the PCD–Cilia–ATP–CFTR Connection
Why primary ciliary dyskinesia may involve more than simply “cilia that don't work”
Primary ciliary dyskinesia (PCD) is an inherited disorder in which the structure, formation, or movement of motile cilia is abnormal. Throughout the respiratory tract, these microscopic hair-like structures normally beat in a coordinated fashion to move mucus, trapped particles, and microorganisms toward the throat, where they can be cleared.
When those cilia don't beat properly, mucociliary clearance is impaired. Mucus and bacteria can remain in the airways, contributing to recurrent respiratory infections, chronic inflammation, progressive airway damage, and bronchiectasis.
But there is another layer to the story.
Read more: Beyond the Beat: Understanding the PCD–Cilia–ATP–CFTR Connection
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